Toward the Identification of Extra-Oral TAS2R Agonists as Drug Agents for Muscle Relaxation Therapies via Bioinformatics-Aided Screening of Bitter Compounds in Traditional Chinese Medicine
Identifieur interne : 000316 ( Main/Exploration ); précédent : 000315; suivant : 000317Toward the Identification of Extra-Oral TAS2R Agonists as Drug Agents for Muscle Relaxation Therapies via Bioinformatics-Aided Screening of Bitter Compounds in Traditional Chinese Medicine
Auteurs : Mingzhi Luo [République populaire de Chine] ; Kai Ni [République populaire de Chine] ; Yang Jin [République populaire de Chine] ; Zifan Yu [République populaire de Chine] ; Linhong Deng [République populaire de Chine]Source :
- Frontiers in Physiology [ 1664-042X ] ; 2019.
Abstract
Significant advances have been made in the past decade in mapping the distributions and the physiological functions of extra-oral bitter taste receptors (TAS2Rs) in non-gustatory tissues. In particular, it has been found that TAS2Rs are expressed in various muscle tissues and activation of TAS2Rs can lead to muscle cell relaxation, which suggests that TAS2Rs may be important new targets in muscle relaxation therapy for various muscle-related diseases. So far, however, there is a lack of potent extra-oral TAS2R agonists that can be used as novel drug agents in muscle relaxation therapies. Interestingly, traditional Chinese medicine (TCM) often characterizes a drug’s property in terms of five distinct flavors (bitter, sweet, sour, salty, and pungent) according to its taste and function, and commonly regards “bitterness” as an intrinsic property of “good medicine.” In addition, many bitter flavored TCM are known in practice to cause muscle relaxation after long term use, and in lab experiments the compounds identified from some bitter flavored TCM do activate TAS2Rs and thus relax muscle cells. Therefore, it is highly possible to discover very useful extra-oral TAS2R agonists for muscle relaxation therapies among the abundant bitter compounds used in bitter flavored TCM. With this perspective, we reviewed in literature the distribution of TAS2Rs in different muscle systems with a focus on the map of bitter flavored TCM which can regulate muscle contractility and related functional chemical components. We also reviewed the recently established databases of TCM chemical components and the bioinformatics software which can be used for high-throughput screening and data mining of the chemical components associated with bitter flavored TCM. All together, we aim to present a knowledge-based approach and technological platform for identification or discovery of extra-oral TAS2R agonists that can be used as novel drug agents for muscle relaxation therapies through screening and evaluation of chemical compounds used in bitter flavored TCM.
Url:
DOI: 10.3389/fphys.2019.00861
PubMed: 31379593
PubMed Central: 6647893
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Toward the Identification of Extra-Oral TAS2R Agonists as Drug Agents for Muscle Relaxation Therapies via Bioinformatics-Aided Screening of Bitter Compounds in Traditional Chinese Medicine</title><author><name sortKey="Luo, Mingzhi" sort="Luo, Mingzhi" uniqKey="Luo M" first="Mingzhi" last="Luo">Mingzhi Luo</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Changzhou Key Laboratory of Respiratory Medical Engineering, Institute of Biomedical Engineering and Health Sciences, Changzhou University</institution>,<addr-line>Changzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ni, Kai" sort="Ni, Kai" uniqKey="Ni K" first="Kai" last="Ni">Kai Ni</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Changzhou Key Laboratory of 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xml:lang="en" level="a" type="main">Toward the Identification of Extra-Oral TAS2R Agonists as Drug Agents for Muscle Relaxation Therapies via Bioinformatics-Aided Screening of Bitter Compounds in Traditional Chinese Medicine</title><author><name sortKey="Luo, Mingzhi" sort="Luo, Mingzhi" uniqKey="Luo M" first="Mingzhi" last="Luo">Mingzhi Luo</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Changzhou Key Laboratory of Respiratory Medical Engineering, Institute of Biomedical Engineering and Health Sciences, Changzhou University</institution>,<addr-line>Changzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ni, Kai" sort="Ni, Kai" uniqKey="Ni K" first="Kai" last="Ni">Kai Ni</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Changzhou Key Laboratory of Respiratory Medical Engineering, Institute of Biomedical Engineering and Health Sciences, Changzhou University</institution>,<addr-line>Changzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jin, Yang" sort="Jin, Yang" uniqKey="Jin Y" first="Yang" last="Jin">Yang Jin</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Bioengineering College, Chongqing University</institution>,<addr-line>Chongqing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yu, Zifan" sort="Yu, Zifan" uniqKey="Yu Z" first="Zifan" last="Yu">Zifan Yu</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Changzhou Key Laboratory of Respiratory Medical Engineering, Institute of Biomedical Engineering and Health Sciences, Changzhou University</institution>,<addr-line>Changzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deng, Linhong" sort="Deng, Linhong" uniqKey="Deng L" first="Linhong" last="Deng">Linhong Deng</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Changzhou Key Laboratory of Respiratory Medical Engineering, Institute of Biomedical Engineering and Health Sciences, Changzhou University</institution>,<addr-line>Changzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Physiology</title><idno type="eISSN">1664-042X</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Significant advances have been made in the past decade in mapping the distributions and the physiological functions of extra-oral bitter taste receptors (TAS2Rs) in non-gustatory tissues. In particular, it has been found that TAS2Rs are expressed in various muscle tissues and activation of TAS2Rs can lead to muscle cell relaxation, which suggests that TAS2Rs may be important new targets in muscle relaxation therapy for various muscle-related diseases. So far, however, there is a lack of potent extra-oral TAS2R agonists that can be used as novel drug agents in muscle relaxation therapies. Interestingly, traditional Chinese medicine (TCM) often characterizes a drug’s property in terms of five distinct flavors (bitter, sweet, sour, salty, and pungent) according to its taste and function, and commonly regards “bitterness” as an intrinsic property of “good medicine.” In addition, many bitter flavored TCM are known in practice to cause muscle relaxation after long term use, and in lab experiments the compounds identified from some bitter flavored TCM do activate TAS2Rs and thus relax muscle cells. Therefore, it is highly possible to discover very useful extra-oral TAS2R agonists for muscle relaxation therapies among the abundant bitter compounds used in bitter flavored TCM. With this perspective, we reviewed in literature the distribution of TAS2Rs in different muscle systems with a focus on the map of bitter flavored TCM which can regulate muscle contractility and related functional chemical components. We also reviewed the recently established databases of TCM chemical components and the bioinformatics software which can be used for high-throughput screening and data mining of the chemical components associated with bitter flavored TCM. All together, we aim to present a knowledge-based approach and technological platform for identification or discovery of extra-oral TAS2R agonists that can be used as novel drug agents for muscle relaxation therapies through screening and evaluation of chemical compounds used in bitter flavored TCM.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Adler, E" uniqKey="Adler E">E. Adler</name></author><author><name sortKey="Hoon, M A" uniqKey="Hoon M">M. A. Hoon</name></author><author><name sortKey="Mueller, K L" uniqKey="Mueller K">K. L. Mueller</name></author><author><name sortKey="Chandrashekar, J" uniqKey="Chandrashekar J">J. Chandrashekar</name></author><author><name sortKey="Ryba, N J P" uniqKey="Ryba N">N. J. P. Ryba</name></author><author><name sortKey="Zuker, C S" uniqKey="Zuker C">C. S. Zuker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alfonso Prieto, M" uniqKey="Alfonso Prieto M">M. 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Xu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Luo, Mingzhi" sort="Luo, Mingzhi" uniqKey="Luo M" first="Mingzhi" last="Luo">Mingzhi Luo</name></noRegion><name sortKey="Deng, Linhong" sort="Deng, Linhong" uniqKey="Deng L" first="Linhong" last="Deng">Linhong Deng</name><name sortKey="Jin, Yang" sort="Jin, Yang" uniqKey="Jin Y" first="Yang" last="Jin">Yang Jin</name><name sortKey="Ni, Kai" sort="Ni, Kai" uniqKey="Ni K" first="Kai" last="Ni">Kai Ni</name><name sortKey="Yu, Zifan" sort="Yu, Zifan" uniqKey="Yu Z" first="Zifan" last="Yu">Zifan Yu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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